Next: Introduction
Dale. E. Tronrud
Howard Hughes Medical Institute
and
Institute of Molecular Biology
University of Oregon
Eugene, OR 97403
January 4, 1994
The process of refinement is a large problem in function minimization. To reduce the amount of computation the methods chosen to minimize the function incorporate a number of assumptions. When these assumptions break down special procedures must be used.
Most of these procedures are commonly known, such as rigid body refinement, but an understanding of the details of the methods themselves allows one to know when and what procedure to apply.