Introduction to Macromolecular Refinement
Introduction
Why Refinement?
PPT Slide
Principle Choices in Refinement
Maximum Likelihood
The Least-squares Function
Different Classes of Observations
Major Limitation of this Equation
Energy Minimization
Methods of Minimization
The Minimization Continuum
Full Matrix Minimization
Full Matrix Minimization (cont.)
Adding History to a Cycle
Minimization Method Summary
When the Off-diagonal Elements are Ignored...
When the Diagonal Elements are Ignored as well...
Things to Watch in Refinement
A Common Mistake
In Conclusion...
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